Chloride substituents modify the physical properties of organic compounds in several ways. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. COA of Formula: C7H8ClN.
Pal, Ritesh;Chakraborty, Jeet;Mukhopadhyay, Titas Kumar;Kanungo, Ajay;Saha, Rimita;Chakraborty, Amit;Patra, Dipendu;Datta, Ayan;Dutta, Sanjay research published 《 Substituent effect of benzyl moiety in nitroquinoxaline small molecules upon DNA binding: Cumulative destacking of DNA nucleobases leading to histone eviction》, the research content is summarized as follows. Cooperative disruption of Watson-Crick hydrogen bonds, as well as base-destacking, was shown to be triggered by a quinoxaline-based small mol. consisting of an N,N-dimethylaminopropyl tether, and a para-substituted benzyl moiety. This events led to superstructure formation and DNA condensation as evident from biophys. experiments and classical mol. dynamics simulations. The DNA superstructure formation by mono-quinoxaline derivatives I [R = 1-piperidyl, [3-(dimethylamino)propylamino]; R1 = benzyl, 2-thienylmethyl, (4-iodophenyl)methyl, etc.] was highly entropically favored and predominantly driven by hydrophobic interactions. Furthermore, oversupercoiling of DNA and base-destacking cumulatively induced histone eviction from in-vitro assembled nucleosomes at lower micromolar concentrations implicating biol. relevance. The DNA structural modulation and histone eviction capacity of the benzyl para-substituents were in the order: -I > -CF3> -Br > -Me > -OMe > -OH, which was largely guided by the polarity of benzyl para-substituent and the resulting mol. topol. The most hydrophobic derivative I [R = [3-(dimethylamino)propylamino], R1 = (4-iodophenyl)methyl] with para-iodo benzyl moiety caused maximal disruption of base pairing and generation of superstructures. Both these events gradually diminished as the polarity of the benzyl para-substituent increases. On the other hand, quinoxaline derivatives I having heterocyclic ring instead of benzyl ring, or in the absence of N,N-dimethylamino head-group, was incapable of inducing any DNA structural change and histone eviction. Further, the quinoxaline compounds I displayed potent anticancer activities against different cancer cell lines which directly correlates with the hydrophobic effects of the benzyl para-substituents. Overall, the study provided new insights into the mechanistic approach of DNA structural modulation driven histone eviction guided by the hydrophobicity of synthesized compounds leading to cellular cytotoxicity towards cancer cells.
COA of Formula: C7H8ClN, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., 104-86-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics