Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Category: chlorides-buliding-blocks.
Nivetha, Narayanasamy;Thangamani, Arumugam research published 《 Dispirooxindole-pyrrolothiazoles: Synthesis, anti-cancer activity, molecular docking and green chemistry metrics evaluation》, the research content is summarized as follows. A modest library of a set of dispirooxindole-pyrrolothiazoles I [Ar = C6H5, 4-MeC6H4, 3-BrC6H4, etc.] were synthesized through multicomponent technique employing 1,3-dipolar cycloaddition reaction of azomethine ylide with dipolarophiles, 2,6-dibenzylidene-4-methylcyclohexanones without any catalyst. The reaction provided simple and efficient access to synthetically useful and biol. important dispirooxindole-pyrrolothiazoles I in high yield (86-98%) with high degree of stereo-, regio-, and chemo-selectivities. All the synthesized compounds I were characterized using popular spectral methods like IR, 1H NMR, 13C NMR and 2D NMR techniques. Further, the mol. structure of I [Ar = 3-ClC6H4] was confirmed by single crystal XRD. The synthesized compounds were subjected to cytotoxicity evaluation using K562-leukemia cell line. Compound I [Ar = 4-benzyloxyphenyl] was found to be an effective compound of this class in targeting K562-leukemia cell with IC50 value of 13.28 ± 0.11μg/mL. From the mol. docking data, it was realized that these compounds showed a binding energy between -8.1 and -10.8 kcal/mol and thereby inhibited tyrosine Kinases. Smaller E-factor (0.13), high atom-economy (89.74%), percentage yield (98.00%), reaction mass efficiency (88.43%), and carbon efficiency (96.97%) were successful achieved for compound I [Ar = 4-FC6H4].
6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics