Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application In Synthesis of 6334-18-5.
Luna, Isadora S.;Neves, Wendell W.;Lima-Neto, Reginaldo G. de;Albuquerque, Amanda P. B.;Pitta, Maira G. R.;Rego, Moacyr J. B. M.;Neves, Rejane P.;Scotti, Marcus T.;Mendonca-Junior, Francisco J. B. research published 《 Design, synthesis and antifungal activity of new schiff bases bearing 2-aminothiophene derivatives obtained by molecular simplification》, the research content is summarized as follows. Seventeen Schiff bases bearing 2-aminothiophene derivatives I (R = 3-NO2C6H4, 4-ClC6H4, 4-nitro-1H-indol-3-yl, etc.) were designed and synthesized using mol. simplification. The resulting compounds were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), and cytotoxic evaluation of the most active compounds were performed. Using an eco-friendly procedure, microwave assisted synthesis resulted in compounds in good yields (35-85%). Compounds I presented good druglikeness and pharmacokinetic profiles and no cytotoxicity for any cell line tested up to 100μM. The compounds presenting the best antifungal profiles were I (R = 2,6-(Cl)2C6H3, 2-NO2C6H4, 3-NO2C6H4, 4-NO2C6H4, 3,4,5-(MeO)3C6H2, C6H5, 4-BrC6H4, 4-nitro-1H-indol-3-yl) with more than one min. inhibitory concentration (MIC) value occurring between 16-64μg mL-1, thus, in some cases better than the reference drug (fluconazole). SAR testing indicated that the presence of halogens and nitro substituents increases antifungal activity. Taken together, the results demonstrate that 2-aminothiophene derivatives are promising lead compounds for the development of antifungal drugs.
Application In Synthesis of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics