Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 3900-89-8.
Li, Xin;Liu, Yunxia;Zhang, Lizhi;Dong, Yunhui;Liu, Qing;Zhang, Daopeng;Chen, Lei;Zhao, Zengdian;Liu, Hui research published 《 A novel electromagnetic mill promoted mechanochemical solid-state Suzuki-Miyaura cross-coupling reaction using ultra-low catalyst loading》, the research content is summarized as follows. The Nobel-prize-winning Suzuki-Miyaura cross-coupling (SMC) is a practical and attractive strategy for the construction of C-C bonds in both academic and industrial settings. However, the development of solid-state SMC reactions remains extremely scarce. Herein, authors report an electromagnetic mill (EMM) promoted solid-state SMC reaction using ultra-low palladium loading (0.05 mol%) without any liquid mol. dispersants. This protocol exhibits substantially broadened substrate scope, good functional group tolerance, efficient gram-scale synthesis and, especially, relatively high yields. The EMM conditions can suppress high aggregation of catalyst and accelerate the mixture of solid reactants, which might be the key for excellent efficiency. The utility of this strategy was exemplified in the modification of photoluminescent mols., cross-coupling of slightly soluble compounds and synthesis of several important bioactive mols. This solid-state EMM-SMC will be potentially developed into industrially attractive and environmentally friendly routes, and the EMM system developed in this study could unlock broad areas of chem. space for solvent-free solid-state metal-catalyzed synthesis of valuable targets in various scientific fields.
3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Quality Control of 3900-89-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics