On February 7, 2020, Yuen, Tsz Ying; Brown, Christopher J.; Tan, Yaw Sing; Johannes, Charles W. published an article.Application of 5034-06-0 The title of the article was Synthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides. And the article contained the following:
α,α’-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α’-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure. Herein, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting helical peptides. The increased potency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by a combined effect of net hydrophobicity and enhanced protein association rates. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0
The Article related to chiral cyclopropane alkenyl amino acid synthesis stapled peptide, solid phase peptide synthesis macrocyclization conformation helix, mdm2 binding fluorescence md simulation enthalpy free energy cluster, glycine derivative horner wadsworth emmons olefination alkenyl aldehyde, condensation reaction stereoselective cyclopropanation and other aspects.Application of 5034-06-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics