On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:
In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2
The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics