On December 31, 2019, He, Zhi-Tao; Hartwig, John F. published an article.Related Products of 98946-18-0 The title of the article was Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds. And the article contained the following:
A generally applicable approach to attach small rings to a wide range of aromatic compounds by palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters was reported. The direct α-arylation of cyclopropyl esters and cyclobutyl esters was achieved in high yield by ensuring that rate of coupling exceeded rate of Claisen condensation. The α-arylation of azetidines was achieved without ring opening of strained saturated heterocycle by conducting reactions with an azetidine derivative bearing a benzyl protecting group on nitrogen. Mechanistic studies showed that α-arylation of small rings was challenging because of the weak acidity of α C-H bond (cyclopropanes), strong sensitivity of strained esters to Claisen condensation (cyclobutatanes), or facile decomposition of enolates (azetidinyl esters). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Related Products of 98946-18-0
The Article related to aryl cyclobutyl ester preparation, cyclobutyl ester aryl bromide alpha arylation palladium catalyst, azetidinyl ester aryl preparation, azetidine ester aryl bromide alpha arylation palladium catalyst, cyclopropyl ester aryl preparation, bromoarene cyclopropyl ester alpha arylation palladium catalyst and other aspects.Related Products of 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics