《Copper-Catalyzed Trifluoromethylation/Cyclization of Alkynes for Synthesis of Dioxodibenzothiazepines》 was written by Zhang, Zi-Qi; Xu, Yi-Hao; Dai, Jing-Cheng; Li, Yan; Sheng, Jie; Wang, Xi-Sheng. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused ontrifluoroethylidene dioxodibenzothiazepine regioselective diastereoselective preparation; ethynylphenyl benzenesulfonamide Tognis reagent copper trifluromethylation tandem radical cyclization. The article conveys some information:
A facile and efficient approach for the synthesis of the CF3-containing dioxodibenzothiazepines was developed via copper-catalyzed trifluoromethylation/cyclization of alkynes utilizing a radical relay strategy. This method showed demonstrated low catalyst loading, high regiocontrol and broad scope under mild conditions. Good compatibility for the N-protecting group, gram-scale experiment, and further derivation of product proved the versatility of this transformation. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics