Zhang, Yurong; Liu, Yafei; Zhang, Jun; Gu, Ren; Han, Shiqing published their research in Tetrahedron Letters on December 5 ,2019. The article was titled 《An alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur》.Quality Control of 3-Chlorobenzylchloride The article contains the following contents:
An elemental sulfur mediated reaction of benzyl chlorides with benzylamines was developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that was metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system was used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equiv to 5 equivalent The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics