Yuan, Huihui; Wang, Mingyue; Fan, Lei; Yang, Jia; Wang, Shuai; Zhong, Hong published their research in Tetrahedron Letters on December 21 ,2021. The article was titled 《A solvent-free method for the preparation of phosphinates from P(O)-OH compounds with alkyl chlorides》.Formula: C7H6Cl2 The article contains the following contents:
Herein, a new solvent-free synthetic method using P(O)-OH compound and alkyl chloride for phosphinate compounds is disclosed. This transformation proceeds smoothly under the promotion of a lone base and presents the advantages of an easily available raw material source, a simple post treatment process, good functional group tolerance and high reaction efficiency. Good yield was obtained when the reaction was magnified to gram scale(coating), and the molar ratio of P(O)-OH compounds and alkyl chlorides can be decreased to 1:2. This protocol provides a practical method for the preparation of phosphorus derivatives Furthermore, the reaction mechanism was explored by 31P NMR. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics