《Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives》 was published in Youji Huaxue in 2020. These research results belong to Wu, Bowen; Cui, Xinxin; Zhu, Ting; Wang, Shenghui; Lu, Chaofan; Wang, Jinjie; Dang, Hexiang; Zhang, Saiyang; Ding, Li-na; Jin, Chengyun. Recommanded Product: 3-Chlorobenzylchloride The article mentions the following:
A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC6H4, 4-FC6H4, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH2C6H4] showed the most potent antitumor activity against PC-3 cells with IC50 value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH2C6H4] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH2C6H4] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics