Electric Literature of C7H6Cl2On May 31, 2022, Wang, Qi; Yao, Lingyun; Wang, Jian-Shu; Ying, Jun; Wu, Xiao-Feng published an article in Molecular Catalysis. The article was 《Palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides with 2-nitroaryl alkynes to construct indole derivatives》. The article mentions the following:
A palladium-catalyzed aminocarbonylative cyclization of benzyl chlorides RCH2Cl (R = Ph, 3,5-dichlorophenyl, naphthalen-1-yl, etc.) with 2-nitroaryl alkynes 2-NO2-4-R1-5-R2C6H2CCR3 (R1 = H, Me, F; R2 = H, Cl; R3 = Ph, n-Bu, cyclopropyl, etc.) has been developed for the rapid construction of indole skeletons I. The reaction utilized nitroarenes as the nitrogen source, Mo(CO)6 as both the CO surrogate and the reductant to furnish various indole derivatives I in moderate to high yields. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics