Schirmer, Tobias E.; Rolka, Alessa B.; Karl, Tobias A.; Holzhausen, Ferdinand; Koenig, Burkhard published their research in Organic Letters in 2021. The article was titled 《Photocatalytic C-H Trifluoromethylthiolation by the Decatungstate Anion》.Application of 5781-53-3 The article contains the following contents:
A broadly applicable method for the trifluoromethylthiolation of methylene C(sp3)-H, methine C(sp3)-H, α-oxygen C(sp3)-H, and formyl C(sp2)-H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applied to 40 examples in good regioselectivities, including the derivatization of natural products. Furthermore, SCF3-drug analogs were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C-H functionalization. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics