In 2022,Sabita, G.; Savitha, R.; Divya, K.; Bhaskar, K. published an article in Chemical Data Collections. The title of the article was 《Synthesis and biological evaluation of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidines as cytotoxicity agents》.Computed Properties of C6H4Cl2O2S The author mentioned the following in the article:
A new bunch of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine compounds I [R = 4-Me, 3,4-di-Cl, 3,4,5-tri-MeO, etc.] was designed, developed and their structure were characterized by anal. techniques. Further, compounds I were tested for their cytotoxicity activities towards human cancer cell lines like SiHa (cervix cancer), A549 (Lung cancer), MCF-7 (Breast cancer) and Colo-205 (colon cancer) using MTT assay and compared with standard drug, etoposide. Among all, compounds, compounds I [R = 3,4,5-tri-MeO, 3,4-di-MeO, 4-MeO, 4-O2N, 4-MeO-3,5-di-O2N] demonstrated good cytotoxicity effects as standard drug. Specifically, two compounds I [R = 3,4,5-tri-MeO, 4-MeO-3,5-di-O2N] displayed more potent activity.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S) was used in this study.
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H4Cl2O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics