Placais, Clotilde; Donnard, Morgan; Panossian, Armen; Vors, Jean-Pierre; Bernier, David; Pazenok, Sergii; Leroux, Frederic R. published their research in Organic Letters in 2021. The article was titled 《Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization》.Synthetic Route of C3H3ClO3 The article contains the following contents:
A synthesis to access rarely described 3-amino-5-fluoroalkylfurans has been developed by cyclization of easily accessible fluorovinamides. This method is rapid and simple and affords the desired furans as hydrochloride salts in quant. or nearly quant. yields. It is compatible with four different fluorinated groups (-CF3, -CF2CF3, -CHF2, and -CF2Cl) and a wide range of substituents on the amine. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics