Hu, Weitao; Lin, Zhiyang; Wang, Chuan published their research in Organic Letters on August 12 ,2022. The article was titled 《Synthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction》.Computed Properties of C7H6Cl2 The article contains the following contents:
Herein, a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides I (R1 = Ph, 1-naphthyl, benzodioxol-5-yl, etc.; R2 = H, Me, phenyl; R3 = H, Ph, furan-2-yl, thiophen-2-yl) was reported, wherein aryl iodides, alkyl iodides, and benzyl chlorides R4X (R4 = Pr, cyclohexyl, phenyl; X = I, Cl) can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcs. R1C(CH(OH)R3)=C(R2)CH2R4. This new method features broad substrate scope multisubstituted allylic alcs., good step-economy, and high L/B- and E/Z selectivity as well as mild reaction conditions.3-Chlorobenzylchloride(cas: 620-20-2Computed Properties of C7H6Cl2) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Computed Properties of C7H6Cl2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics