《Structure-activity relationship study of gatastatin based on the topliss tree approach》 was written by Hayakawa, Ichiro; Shioda, Shuya; Chinen, Takumi; Usui, Takeo; Kigoshi, Hideo. Category: chlorides-buliding-blocks And the article was included in Heterocycles in 2019. The article conveys some information:
Various analogs of gatastatin I [Ar = 3-ClC6H4, 4-MeC6H4, 4-tButC6H4, etc.], a γ-tubulin-specific inhibitor, were designed and synthesized by systematically optimizing the aromatic ring at the O7-benzyl group in accordance with an operational Topliss tree, and their biol. activities were evaluated. Some derivatives showed stronger cytotoxicity against HeLa cells than gatastatin. Especially, the cytotoxicity of the I [Ar = 3-ClC6H4] derivative was about 18-fold stronger than that of gatastatin. However, these derivatives did not exhibit binding ability to the yeast γ-tubulin small complex or inhibitory activity against α,β-tubulin polymerization These results suggested that γ-tubulin strongly recognized the unsubstituted Ph ring of the O7-benzyl group in gatastatin.3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics