《Design and Synthesis of Sulfonamide-Attached 2-(Isoxazol-3-yl)-1H-imidazoles as Anticancer Agents》 was written by Dende, Satheesh Kumar; Korupolu, Raghu Babu; Leleti, Krishnakanth Reddy. Quality Control of 4-Chlorobenzenesulfonyl chloride And the article was included in ChemistrySelect in 2020. The article conveys some information:
Library of 2-(isoxazol-3-yl)-1H-imidazole sulfonamides I [R = H, 4-Me, 3,4-di-Cl, etc.] were synthesized and structures were confirmed by 1HNMR, 13CNMR and mass spectral anal. Further these compounds I were tested for their anticancer activity against four human cancer cell lines, such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as pos. control. Among them, compounds I [R = 2,3,5-tri-MeO, 3,5-di-Cl, 4-MeO, 4-Cl, 4-CN, 4-NO2, 3-NO2] showed more potent anticancer activity against human cancer cell lines.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride) was used in this study.
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics