Akama, Tsutomu; Dong, Chen; Virtucio, Charlotte; Freund, Yvonne R.; Chen, Daitao; Orr, Matthew D.; Jacobs, Robert T.; Zhang, Yong-Kang; Hernandez, Vincent; Liu, Yang; Wu, Anne; Bu, Wei; Liu, Liang; Jarnagin, Kurt; Plattner, Jacob J. published the artcile< Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents>, Application In Synthesis of 162046-61-9, the main research area is benzoxaborole amid preparation structure activity relationship antiinflammatant; Anti-inflammatory; Benzoxaborole; Collagen-induced arthritis; Cytokine; Interleukin-1beta; Interleukin-6; Pharmacokinetics; Structure–activity relationships; Tumor necrosis factor-alpha.
Structure-activity relationships of 6-(benzoylamino)benzoxaborole analogs were investigated for the inhibition of TNF-α, IL-1β, and IL-6 from lipopolysaccharide stimulated peripheral blood mononuclear cells. One compound showed potent activity against all three cytokines with IC50 values between 0.19-0.50 μM, inhibited LPS-induced TNF-α and IL-6 elevation in mice and improved collagen-induced arthritis in mice. This compound is considered to be a promising lead for novel anti-inflammatory agent with an excellent pharmacokinetic profile.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Application In Synthesis of 162046-61-9.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics