The author of 《Chlorination of the esters of anisic acid》 were Szilagyi, Geza; Kasztreiner, Endre; Meszaros, Laszlone; Vargha, Laszlo. And the article was published in Magyar Kemiai Folyoirat in 1969. Synthetic Route of C8H6Cl2O3 The author mentioned the following in the article:
Esters of anisic acid (I) were chlorinated in CHCl3. Cl is passed through a solution of 200 g ethyl ester (II) of I in 40 ml CHCl3 in the presence of 2 g iodine at a rate so that no Cl leaves the reaction mixture The reaction is exothermic and yields 86.5% ethyl 4-methoxy-3,5-dichlorobenzoate, m 60-2°. Similarly were prepared 85.5% Me 4-methoxy-3,5-dichlorobenzoate, m. 75-7° (MeOH), 86.5% Pr 4-methoxy-3,5-dichlorobenzoate, m. 35-7° (EtOH), 76% Bu 4-methoxy-3,5-dichlorobenzoate, m. 28-30° (EtOH). Et 4-methoxy-3-chlorobenzoate, m. 76-6°, was prepared by chlorination of II in the presence of 1% water at 75° (method A) or in the presence of iodine (method B); the yield for method A was 28.8% and for method B 70.5%. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Synthetic Route of C8H6Cl2O3)
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Synthetic Route of C8H6Cl2O3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics