《Synthesis, Characterization and Theoretical Investigation on Thiazoline-Derived Palladium-Complexes-Catalyzed Denitrogenative Cross-Coupling of Aryl Halides with Arylhydrazines》 was published in ChemistrySelect in 2019. These research results belong to Sudharsan, Murugesan; Thirumoorthy, Krishnan; Nethaji, Munirathinam; Suresh, Devarajan. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) The article mentions the following:
Homo- and heteroleptic palladium(II) complexes I, II and III [R = H, Me] of thiazoline derived ligand were synthesized and their catalytic application was reported. The reactions of 2-(4,5-dihydro-2-thiazolyl)phenol with PdCl2 and [(1-(CH3)2NCH2C6H4)PdCl]2 in 2:1 molar ratios afforded the homoleptic palladium complex, I and the heteroleptic palladium complex II resp. Equimolar reactions of 2-(4,5-dihydro-2-thiazolyl)phenol with PdCl2 and 8-quinolinol or 2-methyl-8-quinolinol under reflux condition produced the heteroleptic palladium complexes III [R = H, Me] in good yields. The mol. structures of ligand and palladium complexes I, II, III were confirmed through multinuclear NMR spectroscopic techniques and further the crystal structure for palladium complexes I and II were established. Under the optimized reaction condition, the heteroleptic palladium complex II displayed an excellent catalytic activity with a maximum turn over frequency of 49.5 h-1 for the conversion of biaryls from aryl halides and unactivated phenylhydrazine. The energies, activation barriers and transition state structures of reaction involved in the catalytic cycle were assessed by utilizing quantum chem. method to confirm Csp2-Csp2 bond formation reaction catalyzed by heteroleptic palladium complex II. The results came from multiple reactions, including the reaction of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II))
Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II)(cas: 18987-59-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Di-μ-chlorobis[2-[(dimethylamino)methyl]phenyl-C,N]dipalladium(II) However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics