Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideIn 2019 ,《KI-catalyzed synthesis of S-Thiocarbamates by cross-coupling of cyclohexyl isocyanide with sulfonyl chlorides》 was published in Journal of Chemical Research. The article was written by Lin, Liangwei; Fang, Zhengjun; Li, Yajun; Wu, Feng; Au, Chaktong; Luo, Sai. The article contains the following contents:
A simple and efficient process for direct generation of various S-thiocarbamates I (Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.) is developed by cross-coupling of readily available sulfonyl chlorides with cyclohexyl isocyanide. The yields are excellent and the structures of the generated S-thiocarbamates are characterized by NMR spectroscopy, IR spectroscopy, and high-resolution mass spectrometry together with X-ray crystallog. anal. The protocol has the advantages of using easily available reagents, employs inexpensive KI as the reagent, demonstrates good functional group tolerance, and utilizes mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics