《Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability》 was published in Bioorganic Chemistry in 2020. These research results belong to Lakshmi Manasa, Kesari; Thatikonda, Sowjanya; Sigalapalli, Dilep Kumar; Sagar, Arpita; Kiranmai, Gaddam; Kalle, Arunasree M.; Alvala, Mallika; Godugu, Chandraiah; Nagesh, Narayana; Nagendra Babu, Bathini. COA of Formula: C6H4Cl2O2S The article mentions the following:
A series of new β-carboline linked aryl sulfonyl piperazine congeners I (R = H, Ph, 3,4,5-trimethoxyphenyl, 4-fluorophenyl, etc.; R1 = H, OMe, Me, Cl, t-Bu) have been synthesized by coupling various β-carboline acids II with substituted aryl sulfonyl piperazines III. Evaluation of their anticancer activity against a panel of human cancer cell lines such as colon (HT-29), breast (MDA-MB-231), bone osteosarcoma (MG-63), brain (U87 MG), prostate (PC- 3) and normal monkey kidney (Vero) cell line has been done. Among the series, compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) has shown most potent cytotoxicity with IC50 values of 2.80 ± 0.10μM and 0.59 ± 0.28μM resp. against MG-63 cell line and also potent on other cell lines tested. Compounds I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) were found to inhibit Topo II that is confirmed by specific Topo II inhibition assay. DNA binding studies, cell cycle anal., Annexin V study indicate that these compounds have potential anticancer activity. Mol. docking studies for compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) are incorporated to understand the nature of interaction with topoisomerase IIα and dsDNA. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C6H4Cl2O2S The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics