Kumar, Dhirendra; Maury, Suresh Kumar; Kumari, Savita; Kamal, Arsala; Singh, Himanshu Kumar; Singh, Sundaram; Srivastava, Vandana published an article in 2022. The article was titled 《TBAI-catalyzed C-N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides》, and you may find the article in Synthetic Communications.Name: 1-(Bromomethyl)-4-chlorobenzene The information in the text is summarized as follows:
A new green approach for the synthesis of amide R1PhC(O)NR2R3 [R1 = H, NO2, Cl, etc.; R2 = H, n-Bu., Bn, etc.; R3 = H, Me, Et; R2,R3 = (CH2)4, (CH2)5, (CH2)2O] was developed through TBAI-catalyzed oxidative coupling of benzyl bromides with amines in the presence of tert-Bu hydroperoxide as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines were subjected to the reaction and transformed to the corresponding amide in good to excellent yields. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics