Jian, Jie; Hammink, Roel; McKenzie, Christine J.; Bickelhaupt, F. Matthias; Poater, Jordi; Mecinovic, Jasmin published their research in Chemistry – A European Journal in 2021. The article was titled 《Do Sulfonamides Interact with Aromatic Rings?》.Recommanded Product: (3-Fluorophenyl)boronic acid The article contains the following contents:
Aromatic rings form energetically favorable interactions with many polar groups in chem. and biol. systems. Recent mol. studies have shown that sulfonamides can chelate metal ions and form hydrogen bonds, however, it is presently not established whether the polar sulfonamide functionality also interacts with aromatic rings. Here, synthetic, spectroscopic, structural, and quantum chem. analyses on 2,6-diarylbenzenesulfonamides are reported, in which two flanking aromatic rings are positioned close to the central sulfonamide moiety. Fine-tuning the aromatic character by substituents on the flanking rings leads to linear trends in acidity and proton affinity of sulfonamides. This phys.-organic chem. study demonstrates that aromatic rings have a capacity to stabilize sulfonamides via through-space NH-π interactions. These results have implications in rational drug design targeting electron-rich aromatic rings in proteins. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: (3-Fluorophenyl)boronic acid) was used in this study.
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: (3-Fluorophenyl)boronic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics