《Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR》 was written by Hu, Junbo; Zhang, Yanli; Tang, Na; Lu, Yanju; Guo, Peng; Huang, Ziming. Quality Control of 4-Chlorobenzenesulfonyl chlorideThis research focused ontriazine preparation cervical antitumor activity enzyme inhibitor SAR; 1,3,5-triazine; Apoptosis; Cell cycle; Cell viability; Cervical cancer; PI3K; mTOR. The article conveys some information:
This study describes the synthesis of novel 1,3,5-triazine derivatives I (R = H, 2-OMe, 3-NO2, 4-Cl, etc.) as potent inhibitors of cervical cancer. The compounds I were initially tested for inhibition of PI3K/mTOR, where they showed significant inhibitory activity. The top-ranking mol. [compound I (R = 4-OH) (II)] was further tested against class I PI3K isoforms, such as PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, where it showed the most significant activity against PI3Kα. Compound II was then tested for anti-cancer activity against triple-neg. breast cancer cells (MDA-MB321), human breast cancer cells (MCF-7), human cervical cancer cells (HeLa) and human liver cancer cells (HepG2), and it showed the greatest potency against HeLa cells. The effects of compound II were further evaluated against the HeLa cells, where it showed significant attenuation of cell viability by inducing cell cycle arrest in the G1 phase. Compound II induced apoptosis and reduced migration and invasion of HeLa cells. Western blotting anal. showed that II inhibited PI3K and mTOR with pos. modulation of Bcl-2 and Bax levels in HeLa cells. The effects of compound II were also investigated in a tumor xenograft mouse model, where it showed reduction of tumor volume and weight It also inhibited the PI3K/Akt/mTOR signaling cascade in xenograft tumor tissues, as evidenced by western blotting anal. The results of the present study suggest the possible utility of the designed 1,3,5-triazine derivative I as a potent inhibitor of cervical cancer. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 4-Chlorobenzenesulfonyl chloride
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics