In 2022,Gao, Yuting; Sun, Yang; Fang, Xianfu; Zhao, Guixian; Li, Xufeng; Zhang, Gong; Li, Yangfeng; Li, Yizhou published an article in Organic Chemistry Frontiers. The title of the article was 《Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries》.Synthetic Route of C4H3ClO2S2 The author mentioned the following in the article:
The DNA-encoded chem. library (DEL) technol. is a novel drug discovery tool, benefiting from its large number of compound collections with chem. space coverage. Vinyl sulfone is a privileged functional group, eliciting diverse pharmacol. activities as the covalent warhead. In this report, we incorporated vinyl sulfone into the DEL chem. field by developing a mild and efficient DNA-compatible method starting from simple sodium sulfinates and DNA-conjugated alkenes, affording a broad substrate scope with moderate-to-excellent conversions. Further chem. transformations including the thiol-Michael addition reaction, together with enzymic ligation, were also successfully implemented to demonstrate the feasibility of this DNA-compatible synthesis in DEL construction. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics