《Synthesis and biological activity of 5-aryliden-2-thiohydantoin S-aryl derivatives》 was published in Bioorganic Chemistry in 2020. These research results belong to Finko, Alexander V.; Skvortsov, Dmitry A.; Laikov, Dimitri N.; Averochkin, Gleb M.; Dlin, Egor A.; Kalinina, Marina A.; Aladinskiy, Vladimir A.; Vorobyeva, Nataliya S.; Mironov, Andrei V.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Ivanenkov, Yan A.; Majouga, Alexander G.. Product Details of 768-35-4 The article mentions the following:
Three new and complementary approaches to S-arylation of 2-thiohydantoins I (R1 = OEt, CN, F, etc.; R2 = H, F, Cl; R3 = H, Br) have been developed: copper-catalyzed cross coupling with either arylboronic acids 4-R4,3-R5 C6H3B(OH)2 (R4 = H, Me, OMe, F, Cl, CN, NO2; R5 = H, F, OMe, CF3) or aryl iodides 2-R8-3-R7-4-R6C6H2I (R6 = OMe, Me, Cl, H, etc.; R7 = H, CF3; R8 = H, NO2) under mild conditions, or direct nucleophilic substitution in activated aryl halides 2-R10-4-R9C6H3X (X = I, F; R9 = NO2; R10 = NO2, H). For 38 diverse compounds, II reaction yields for all three methods have been determined Selected by mol. docking, they have been tested on androgen receptor activation, and p53-Mdm2 regulation, and A549, MCF7, VA13, HEK293T, PC3, LnCAP cell lines for cytotoxicity, wherein two of them are turned out to be promising as androgen receptor activators (likely by allosteric regulation), and another one is shown to activate the p53 cascade. It is hoped that 2-thiohydantoin S-arylidenes are worth for further studies as biol. active compounds After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics