In 2022,Yuan, Ye; Guo, Dou; Liu, Yibo; Wan, Congcong; Lu, Dongbiao; Yang, Hongxiang; Lu, Yufan; Meng, Wei; Wang, Hongling; Zhang, Xiang published an article in European Journal of Organic Chemistry. The title of the article was 《Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group》.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:
A regioselective and nucleophilic halogenation of electron-rich amidophenols was realized in the presence of Fe(III) reagents and amido-directing groups. Halides could be sequentially introduced to specific positions to form mono-, di- and mixed di- halogenated amidophenols I [R = 3-NHC(O)Ph, 2-NHC(O)Ph, 2-NHC(O)Cy, etc.; X = 4-Cl, 4-Br, 2-Br-4-Cl, etc.] using using ferric chloride/bromide . Furthermore, this protocol provided new methods for the syntheses of IKK2 inhibitor (IMD-0354), muscle relaxant (Chlorzoxazone) and related derivatives The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics