《Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria》 was published in New Journal of Chemistry in 2019. These research results belong to Nasim, Muhammad Jawad; Witek, Karolina; Kincses, Annamaria; Abdin, Ahmad Yaman; Zeslawska, Ewa; Marc, Malgorzata Anna; Gajdacs, Mario; Spengler, Gabriella; Nitek, Wojciech; Latacz, Gniewomir; Karczewska, Elzbieta; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga; Jacob, Claus. Electric Literature of C7H6Cl2 The article mentions the following:
Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC50 = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics