In 2022,Kumar N, Manoj; Nukala, Satheesh Kumar; Swamy T, Narasimha; M, Ravinder; Krishna, Thupurani Murali; Narsimha, Sirassu published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole-[1,2,3]triazolo[5,1-a]isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:
The CuI catalyzed synthesis of some novel fused benzothiazole-1,2,3-triazole hybrids I (R = H, 5-Me, 4,6-dichloro, 4,5,6-trimethoxy, etc.) in one-pot was reported . The in vitro anticancer activity of these compounds revealed that the compounds I (R = 5-Cl (II), 5-F (III), 5-nitro (IV), 4,5,6-trimethoxy (V), 4,6-dimethoxy (VI)) showed superior activity against human cancer cell lines like MCF-7, A-549, DU-145 and HeLa than the standard Etoposide. Remarkably, the in vitro tubulin polymerization inhibitory assay of compounds (II), (III), (IV), (V) and (VI) revealed that the compounds (III) and (IV) showed superior activity than the standard CA-4, while the compounds (II), (V) and (VI) were shown comparable activity with the CA-4. Besides, the results of in vitro and in silico ADME studies of most potent compounds (III), (V), (VI), (III) and (IV) were supported the corresponding in vitro anticancer activity data. Finally, the mol. docking studies of compounds I on human γ-tubulin receptor suggested that the most potent compounds (III), (V), (VI), (II) and (IV) strongly bind to the protein and energy calculations were in good agreement with the corresponding IC50 values. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics