Dai, Xing-Jie; Liu, Min; Zhang, Jia-Yan; Xu, Xiao-Ying; Yuan, Wei-Cheng; Zhang, Xiao-Mei published the artcile< A Facile Direct Synthesis of 3-Methyleneisoindolin-1-ones by Annulation of Methyl 2-Acylbenzoates with Amines>, Synthetic Route of 118-45-6, the main research area is methyleneisoindolinone preparation; amine methyl acylbenzoate annulation; ammonium acetate methyl acylbenzoate annulation.
A wide variety of 3-methyleneisoindolin-1-ones I [R1 = H, 4-F, 5-Cl, etc.; R2 = H, Me, Et, etc.; R3 = H, Me, Ph, etc.] were prepared by annulation of Me 2-acylbenzoates with amines or ammonium acetate. The reactions proceeded smoothly to afford the desired products in up to quant. yields.
ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Synthetic Route of 118-45-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics