In 2022,Ciccone, Lidia; Nencetti, Susanna; Camodeca, Caterina; Ortore, Gabriella; Cuffaro, Doretta; Socci, Simone; Orlandini, Elisabetta published an article in Pharmaceutical Chemistry Journal. The title of the article was 《Synthesis and Evaluation of Monoaryl Derivatives as Transthyretin Fibril Formation Inhibitors》.HPLC of Formula: 622-95-7 The author mentioned the following in the article:
Here, the synthesis of new 2-((benzyloxy)imino)acetic, -propanoic and -butanoic acid derivatives, RCH2ON=C(R1)C(O)OH (R = 2-chlorophenyl, 4-methoxyphenyl, 2,4-dichlorophenyl, etc.; R1 = H, Me, Et) results of their turbidimetric UV assay and the docking study of new monoaryl compounds were reported. The obtained results suggest that, for this class of compounds, (i) the chlorine atom in ortho position on the aromatic ring is the best substituent; (ii) the linker inversion still allows the interaction with thyroxine binding sites; and (iii) the steric hindrance in R1 position is detrimental for the activity. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics