Quality Control of 4-Chlorobenzenesulfonyl chlorideIn 2021 ,《Structure based design, synthesis and evaluation of new thienopyrimidine derivatives as anti-bacterial agents》 was published in Journal of Molecular Structure. The article was written by Malasala, Satyaveni; Polomoni, Anusha; Ahmad, Naiyaz Md.; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunav; Chopra, Sidharth; Nanduri, Srinivas. The article contains the following contents:
A number of TrmD inhibitors including thienopyrimidines and fused thienopyrimidines were reported as potent antibacterial and anti-mycobacterial agents. A library of ∼200 structurally diverse thienopyrimidines were designed and subjected to preliminary in-silico studies. Among the library of compounds, 22 thienopyrimidines and fused thienopyrimidines compounds I [R = Ph,2-MeC6H4, 2,4-di-ClC6H3, etc.] II and III [R2 = benzyl, 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl, etc.] were selected, synthesized and were evaluated for their inhibitory activities against a panel of pathogens consisting E. coli, S. aureus, K. pneuminiae, A. baumannii and P. aeruginosa and M. tuberculosis (ATCC 27294). Among the tested compounds, II [R = 2-ClC6H4] III [R2 = benzyl, 3-nitrobenzyl, (2,4-dichlorophenyl)methyl, 2-oxo-2-(p-tolyl)ethyl, 2-(2-naphthyl)-2-oxo-ethyl] were found to inhibit M. tuberculosis (ATCC 27294) with the MIC of 16-32μg/mL. The compounds III [R2 = 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl] were found to be selective against S. aureus with the MIC of 4μg/mL and moderate activity against M. tuberculosis. The selected compounds were further subjected to docking, 3D-QSAR and ADMET studies to understand the mechanism of action and also their physico chem. profile. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics