Joolakanti, Hima Bindhu; Battu, Satyanarayana; Kamepalli, Ramanjaneyulu; Kolanupaka, Harichandana Reddy; Bobbili, Hasika Reddy published their research in Chemical Data Collections in 2021. The article was titled 《Synthesis, docking and biological activities of novel chromone linked [1,2,3]-triazole derivatives》.Synthetic Route of C7H6BrCl The article contains the following contents:
A series of chromone linked [1,2,3]triazoles I [R = C6H5, 3-MeC6H4, 3-ClC6H4, etc.] were designed based on literature followed by in-silico studies. The in-silico studies indicated good docking score for compounds I when docked into the Human Estrogen Receptor Alpha Ligand-Binding Domain (PDB ID: 1XP6). So compounds I were synthesized, characterized and evaluated for cytotoxicity, antibacterial and antioxidant activities. The compounds I [R = C6H5, 4-ClC6H4] showed promising cytotoxicity with IC50 value of 18.61 and 20.39μg/mL resp. The Compounds I [R = 2-FC6H4, 3-FC6H4, 4-ClC6H4, 2-MeC6H4, 2,4-di-ClC6H3] showed encouraging antioxidant activity with IC50 value of < 30μM i.e. DPPH scavenging activity levels more than that of pos. control, whereas compounds I [R = C6H5, 3-FC6H4, 3-ClC6H4, 4-ClC6H4, 3-MeC6H4, 2,4-di-ClC6H3] exhibited moderate antibacterial activities with the MIC value of <240μM. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics