《Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series》 was written by Benmohammed, Abdelmadjid; Rekiba, Nawel; Sehanine, Yassine; Louail, Ahmed Amine; Khoumeri, Omar; Kadiri, Mokhtaria; Djafri, Ayada; Terme, Thierry; Vanelle, Patrice. Quality Control of 3-Chlorobenzylchloride And the article was included in Monatshefte fuer Chemie on August 31 ,2021. The article conveys some information:
New thiosemicarbazones I [R1 = H, 3-Cl, 4-F, etc.; R2 = H, OMe] were synthesized via condensation of N-benzylindole-3-carboxaldehydes with N4-substituted thiosemicarbazides in excellent yield. These thiosemicarbazones I were reacted with Et bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group II. Anal. IR and NMR spectra and elemental anal. were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-pos. and Gram-neg. bacteria. Antibacterial screening data showed that two compounds I and II demonstrated activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. These preliminary results indicated that newly synthesized compounds such as I [R1 = 3-Cl, R2 = OMe] and II [R1 = H, R2 = H] showed a promising antibacterial potency.3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride) was used in this study.
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics