Quality Control of Methyl 2-chloro-2-oxoacetateIn 2020 ,《Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Atack, Thomas C.; Raymond, Donald D.; Blomquist, Christa A.; Pasaje, Charisse Flerida; McCarren, Patrick R.; Moroco, Jamie; Befekadu, Henock B.; Robinson, Foxy P.; Pal, Debjani; Esherick, Lisl Y.; Ianari, Alessandra; Niles, Jacquin C.; Sellers, William R.. The article conveys some information:
FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of these drugs, there is a need for compounds that selectively inhibit FKBP35 and lack the undesired side effects. In contrast to human FKBPs, FKBP35 contains a cysteine, C106, adjacent to the rapamycin binding pocket, providing an opportunity to develop targeted covalent inhibitors of Plasmodium FKBP35. Here, we synthesize inhibitors of FKBP35, show that they directly bind FKBP35 in a model cellular setting, selectively covalently modify C106, and exhibit antiplasmodium activity in blood-stage cultured parasites. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics