In 2019,Angewandte Chemie, International Edition included an article by Yuan, Si-Wen; Han, Hui; Li, Yan-Lin; Wu, Xueli; Bao, Xiaoguang; Gu, Zheng-Yang; Xia, Ji-Bao. Quality Control of 4-Chlorobenzenesulfonyl chloride. The article was titled 《Intermolecular C-H Amidation of (Hetero)arenes to Produce Amides through Rhodium-Catalyzed Carbonylation of Nitrene Intermediates》. The information in the text is summarized as follows:
Amide bond formation is one of the most important reactions in organic chem. because of the widespread presence of amides in pharmaceuticals and biol. active compounds Existing methods for amides synthesis are reaching their inherent limits. Described herein is a novel rhodium-catalyzed three-component reaction to synthesize amides from organic azides, carbon monoxide, and (hetero)arenes via nitrene-intermediates and direct C-H functionalization. Notably, the reaction proceeds in an intermol. fashion with N2 as the only byproduct, and neither directing groups nor additives are required. The computational and mechanistic studies show that the amides are formed via a key Rh-nitrene intermediate. Thus, e.g., 1-methylindole + CO + TsN3 → 1-methyl-N-tosylindole-3-carboxamide (92%, 88% isolated) in presence of [Rh(cod)Cl]2 in MeCN. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 4-Chlorobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics