HPLC of Formula: 620-20-2On May 6, 2020 ,《Reagent Control Enables Selective and Regiodivergent Opening of Unsymmetrical Phenonium Ions》 appeared in Journal of the American Chemical Society. The author of the article were Xu, Shiyan; Holst, Hannah M.; McGuire, Shelby B.; Race, Nicholas J.. The article conveys some information:
The first examples of selective and regiodivergent chlorination of unsym. benzyl-substituted epoxides, I [R = 4-methoxyphenyl, Ph, 2H-1,3-benzodioxol-5-yl, 1-[(4-methylbenzene)sulfonyl]-2,3-dihydro-1H-indol-5-yl, etc.; R1 = Pr, 4-methoxyphenyl, 4-cyanobutyl, 4-(benzyloxy)butyl, etc.] have been reported. These reactions are enabled by the dual role of SnCl4 and TiCl4 as Lewis acids and chloride nucleophiles. Reagent control dictates addition of chloride at either the substituted internal position (SnCl4) or unsubstituted terminal position (TiCl4) of the phenonium ion. These reactions are highly selective, stereospecific, and operationally simple, and proceed in good to excellent yields. Diverse product utility is demonstrated. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2HPLC of Formula: 620-20-2)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.HPLC of Formula: 620-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics