Tian, Yue-E.; Sun, Di; Han, Xiao-Xiao; Yang, Jin-Ming; Zhang, Song; Feng, Nan-Nan; Zhu, Li-Na; Xu, Zhong-Yuan; Che, Zhi-Ping; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang published their research in Journal of Asian Natural Products Research in 2021. The article was titled 《Synthesis, anti-oomycete activity and SAR studies of paeonol derivatives》.Computed Properties of C4H3ClO2S2 The article contains the following contents:
Three series of sulfonate derivatives I [R1 = H, OMe; R2 = H, C(O)Me; R3 = Et, Ph, 4-FC6H4, etc.] of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, resp. Among all the compounds I [R1 = OMe; R2 = C(O)Me; R3 = 4-Cl-3-O2NC6H3], displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 26.87 mg/L, resp. The results showed that acetyl and 4-OMe were two necessary groups. The existence of these two sites was closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group was well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics