Name: Ethyl 3-(4-chlorophenyl)propanoateOn September 30, 2011 ,《Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics》 was published in Latin American Journal of Pharmacy. The article was written by Ramaraj, Sivakumar; Vasanthakumari, Pradeepchandran R.; Narasimha, Jayaveera K.; Rajarathnam, Vijaianand; Palani, Kumamallasivan; Panneerselvam, Arulraj; Ramasamy, Venkatnarayanan. The article contains the following contents:
The type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive target for their efficacy against infections caused by multistrain-resistant Gram-pos. and Gram-neg. bacteria. Among the related FAS II enzymes, beta keto acyl-acyl carrier protein synthase [KAS 3-oxoacyl-[acyl carrier protein] synthase ], is an essential target for novel antibacterial drug design. Several 3-(phenyl)propanoic acid esters (I) were designed, the synthesis of the target compounds was achieved by a multistep process and the products were characterized. I were screened for their inhibitory activity against Escherichia coli β-keto acyl-acyl carrier protein synthase III (ecKAS III) was investigated by mol. docking simulation. I which posses both good inhibitory activity and binding affinity were compared their antibacterial activities against Gram-neg. and Gram-pos. bacterial strains, expecting to discover broad-spectrum antibacterial activity. I displayed significant activity and Et 3-(4-chlorophenyl)propanaoate exhibited the highest antibacterial activity against all tested bacteria. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Ethyl 3-(4-chlorophenyl)propanoate
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics