Naganawa, Atsushi; Saito, Tetsuji; Nagao, Yuuki; Egashira, Hiromu; Iwahashi, Maki; Kambe, Tohru; Koketsu, Masatoshi; Yamamoto, Hiroshi; Kobayashi, Michiyoshi; Maruyama, Takayuki; Ohuchida, Shuichi; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki published the artcile< Discovery of new chemical leads for selective EP1 receptor antagonists>, COA of Formula: C8H7ClO3, the main research area is prostanoid receptor antagonist phenylsulfonyl benzoate preparation SAR.
A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE2 antagonists with selectivity for the EP1 receptor subtype starting from a chem. lead I, which was found while screening our inhouse compound library. Discovery of the optimized analogs is presented here and structure-activity relationships (SAR) are also discussed.
Bioorganic & Medicinal Chemistry published new progress about Prostanoid receptor PTGER4 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics