Mishra, Aniket; Bhowmik, Arup; Samanta, Siddhartha; Sarkar, Writhabrata; Das, Sumit; Deb, Indubhusan published the artcile< Diastereoselective Spirocyclization of Benzoxazines with Nitroalkenes via Rhodium-Catalyzed C-H Functionalization/Annulation Cascade under Mild Conditions>, Computed Properties of 5153-70-8, the main research area is tetrahydrospirobenzooxazineindene diastereoselective preparation; benzoxazine nitroalkene diastereoselective spirocyclization rhodium catalyst.
A Rh(III)-catalyzed [3 + 2] annulation of benzoxazines with nitroolefins that proceeds via redox-neutral C-H functionalization has been demonstrated, leading to the novel class of spirocycles in a single step. The construction of three continuous stereogenic centers has been achieved starting from easily accessible achiral substrates in an atom-efficient manner under mild reaction conditions. A broad range of pharmaceutically relevant nitro substituted spirocyclic 2,3-dihydro-1,4-benzoxazine derivatives has been synthesized in good to excellent yields with high diastereoselectivity.
Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Computed Properties of 5153-70-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics