MacLeod, Angus M.; Baker, Raymond; Freedman, Stephen B.; Patel, Shailendra; Merchant, Kevin J.; Roe, Michael; Saunders, John published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and muscarinic activities of 1,2,4-thiadiazoles》.Application of 38362-15-1 The author mentioned the following in the article:
A series of novel 1,2,4-thiadiazoles bearing a mono- or bicyclic amine at C-5 were prepared Quinuclidine and 1-azabicyclo[2.2.1]heptane derivatives e.g., I (R = H, Me, Et, Me2CH, cyclopropyl, CH2Ph, OMe; n = 1, 2) were synthesized by reaction of the lithium enolate of the 3-methoxycarbonyl compounds followed by ester hydrolysis and decarboxylation. The receptor binding affinity and efficacy of these compounds as muscarinic ligands was assessed by radioligand binding assays using [3H]-N-methylscopolamine and [3H]oxotremorine-M. Optimal agonist affinity was observed for 3′-Me compounds Smaller substituents (H) retained efficacy with reduced affinity while larger groups led to substantially lower efficacy. The observed binding affinity was influenced both by the conformational energy of rotation around the C(3)-C(5′) bond and the steric requirement of the mono- or bicyclic amine. In the experimental materials used by the author, we found 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application of 38362-15-1)
5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 38362-15-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics