《Design, synthesis, and anticancer evaluation of novel benzopyran 1,3,4-oxadiazole derivatives》 was published in Indian Journal of Heterocyclic Chemistry in 2020. These research results belong to Kumar, Piyush; Rahman, Azizur Md.; Wal, Pranay; Rawat, Pinki; Singh, Kuldeep. SDS of cas: 622-95-7 The article mentions the following:
Some new benzopyran 1,3,4-oxadiazole, derivatives I (R = H, benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl; R1 = benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl, 3-chlorobenzyl) were designed by docking, in silico absorption, distribution, metabolism, excretion (ADME) and predicted toxicity studies, and then synthesized by S-alkylation of a benzopyran 1,3,4-oxadiazole derivative with different chloro-substituted benzyl bromides. The synthesized compounds were tested for anticancer activity on the MCF-7 cell line. Docking study showed all compounds to have better docking scores than the standard, Adriamycin. In silico, ADME and toxicity studies were also found as significant for most of the compounds The majority of the compounds displayed good to potent anticancer activity on the MCF-7 cell line. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics