In 1976,European Journal of Medicinal Chemistry included an article by Flammang, Michel; Wermuth, Camille G.. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate. The article was titled 《2,3-Benzodiazepine systems. II. 4-Oxo-3,5-dihydro(4H)-2,3-benzodiazepines. Synthesis and pharmacological study》. The information in the text is summarized as follows:
Benzodiazepinones I (R = H, Cl; R1 = H, Me; R2 = H, Me, morpholinoethyl, morpholinopropyl, pyrrolidinoethyl; R3 = H, OMe, Cl) (11 compounds) were prepared by treating 4-RC6H4CHO with CH2(CO2H)2, cyclizing 4-RC6H4CH:CHCO2H, treating II (X = O) with 4-R3C6H4MgBr, dehydrating II (X = OH,C6H4R3-4), oxidizing the indenes, and condensing 4,2-R(4-R3C6H4CO)C6H3CH2CO2H with R2NHNH2. I had much lower tranquilizing activity than diazepam. In the experimental materials used by the author, we found Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of Ethyl 3-(4-chlorophenyl)propanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics