《Exploring the Relationship between BODIPY Structure and Spectroscopic Properties to Design Fluorophores for Bioimaging》 was published in Chemistry – A European Journal in 2020. These research results belong to Donnelly, Joanna L.; Offenbartl-Stiegert, Daniel; Marin-Beloqui, Jose M.; Rizzello, Loris; Battaglia, Guiseppe; Clarke, Tracey M.; Howorka, Stefan; Wilden, Jonathan D.. Product Details of 5781-53-3 The article mentions the following:
Designing chromophores for biol. applications requires a fundamental understanding of how the chem. structure of a chromophore influences its photophys. properties. We here describe the synthesis of a library of BODIPY dyes, exploring diversity at various positions around the BODIPY core. The results show that the nature and position of substituents have a dramatic effect on the spectroscopic properties. Substituting in a heavy atom or adjusting the size and orientation of a conjugated system provides a means of altering the spectroscopic profiles with high precision. The insight from the structure-activity relationship was applied to devise a new BODIPY dye with rationally designed photochem. properties including absorption towards the near-IR region. The dye also exhibited switch-on fluorescence to enable visualization of cells with high signal-to-noise ratio without washing-out of unbound dye. The BODIPY-based probe is non-cytotoxic and compatible with staining procedures including cell fixation and immunofluorescence microscopy. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics