COA of Formula: C4H3ClO2S2In 2022 ,《Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: A New Mode of Breslow Intermediate Oxidation》 was published in Journal of the American Chemical Society. The article was written by Deng, Rui; Wu, Shuquan; Mou, Chengli; Liu, Jianjian; Zheng, Pengcheng; Zhang, Xinglong; Chi, Yonggui Robin. The article contains the following contents:
A carbene-catalyzed sulfonylation reaction between enone aryl aldehydes and sulfonyl chlorides is disclosed. The reaction effectively installs sulfone moieties in a highly enantioselective manner to afford sulfone-containing bicyclic lactones. The sulfonyl chloride behaves both as an oxidant and a nucleophilic substrate (via its reduced form) in this N-heterocyclic carbene (NHC)-catalyzed process. The NHC catalyst provides both activation and stereoselectivity control on a very remote site of enone aryl aldehyde substrates. Water plays an important role in modulating catalyst deactivation and reactivation routes that involve reactions between NHC and sulfonyl chloride. Exptl. studies and DFT calculations suggest that an unprecedented intermediate and a new oxidation mode of the NHC-derived Breslow intermediate are involved in the new asym. sulfonylation reaction. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9COA of Formula: C4H3ClO2S2)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. COA of Formula: C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics