《Synthesis and insecticidal activity of sulfonate derivatives of sesamol against Mythimna separata in vivo》 was written by Che, Zhi-Ping; Yang, Jin-Ming; Shan, Xi-Jie; Tian, Yue-E.; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Hu, Mei; Chen, Gen-Qiang. Reference of Thiophene-2-sulfonyl chloride And the article was included in Journal of Asian Natural Products Research in 2020. The article conveys some information:
A series of sulfonate derivatives of sesamol were synthesized and evaluated for their insecticidal activity against a crop-threatening agricultural pest, the pre-third-instar larvae of Mythimna separata in vivo. Among all the target compounds, compounds , , and exhibited more promising insecticidal activity than sesamol and toosendanin, and the final mortality rates (FMRs) of , , , , and toosendanin were 60.7%/60.7%/67.9%/53.6%/32.1%/50.0%, resp. Especially compound exhibited the most potent insecticidal activity with FMRs of 67.9%. This suggested that a 4-fluorophenylsulfonyl group introduced at the hydroxyl position of sesamol was necessary for obtaining the most potent compound The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics