Xiong, Jin; Liu, Yunyun published the artcile< Transition-Metal-free C5, C7-Dihalogenation and the Switchable C5 Halogenation of 8-Hydroxyquinolines>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is dihalogenated hydroxyquinoline preparation; hydroxyquinoline acyl chloride halosuccinimide dihalogenation; halogenated hydroxyquinoline preparation; quinolinyl benzoate halosuccinimide halogenation.
The first example of the C5, C7-dihalogenation of 8-hydroxyquinolines based on an in situ O-acyl 8-hydroxyquinoline formation was realized under catalyst-free condition in toluene to synthesize 5,7-dihalogenated-8-hydroxyquinolines I [Ar = Ph, 4-FC6H4, 3-ClC6H4, etc.; R = H, 2-Me; X = Cl, Br, I]. Modifying the reaction conditions by directly utilizing O-acylated 8-hydroxyquinolines in the presence of AlCl3 enabled the electrophilic halogenation in the C5 position, led to the tunable synthesis of C5 halogenated products. The O-acyl group could be easily removed from the product to provide halogenated quinolines containing free hydroxyl group by simple hydrolysis.
ChemistrySelect published new progress about Esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics